Omeprazole 20 mg
Prilosec OTC and its twins. Acid reducer. Active ingredients: Omeprazole 20 mg.
19 options at Costco, Walmart, Amazon, Target, Kroger, CVS, Walgreens. Cheapest: 29¢ per tablet; typical Prilosec OTC: 91¢ per tablet. Prices are estimates from Oct 2026.
Cheapest options
- Kirkland Signature Omeprazole Delayed-Release Tablets 20 mg — Costco, 42 tablets, $11.99 (29¢ per tablet)
- Equate Omeprazole Delayed-Release Tablets 20 mg — Walmart, 42 tablets, $13.48 (32¢ per tablet)
- Amazon Basic Care Omeprazole Delayed-Release Tablets 20 mg — Amazon, 42 tablets, $13.99 (33¢ per tablet)
- up&up Omeprazole Delayed-Release Tablets 20 mg — Target, 42 tablets, $15.99 (38¢ per tablet)
- Kroger Omeprazole Delayed-Release Tablets 20 mg — Kroger, 42 tablets, $17.99 (43¢ per tablet)
- Prilosec OTC Omeprazole Delayed-Release Tablets 20 mg — Amazon, 42 tablets, $26.49 (63¢ per tablet)
- Prilosec OTC Omeprazole Delayed-Release Tablets 20 mg — Walmart, 42 tablets, $26.97 (64¢ per tablet)
- CVS Health Omeprazole Delayed-Release Tablets 20 mg — CVS, 42 tablets, $26.99 (64¢ per tablet)
Where to find it
Look for the “Digestive Health” aisle sign.
Good to know
- Prilosec OTC's Drug Facts list omeprazole 20 mg per tablet, equivalent to 20.6 mg omeprazole magnesium — a store box printing either figure has the same omeprazole dose.
- A 42-tablet box is three 14-day courses, and a 14-tablet box is one course — compare by tablet, not by box.
- "Omeprazole and sodium bicarbonate" capsules (compare to Zegerid OTC) also contain 1,100 mg sodium bicarbonate — a different product, not in this group.