Acetaminophen 325 mg / Dextromethorphan HBr 15 mg / Doxylamine Succinate 6.25 mg (Nighttime)
Vicks NyQuil and its twins. Pain reliever / fever reducer; cough suppressant; antihistamine. Active ingredients: Acetaminophen 325 mg + Dextromethorphan HBr 15 mg + Doxylamine succinate 6.25 mg.
14 options at Walmart, Amazon, Kroger, CVS, Walgreens, Target. Cheapest: 25¢ per softgel; typical Vicks NyQuil: 52¢ per softgel. Prices are estimates from Oct 2026.
Cheapest options
- Equate NiteTime Cold & Flu Multi-Symptom Relief Softgels — Walmart, 24 softgels, $5.97 (25¢ per softgel)
- Amazon Basic Care Nighttime Cold & Flu Softgels — Amazon, 24 softgels, $6.99 (29¢ per softgel)
- Kroger Nighttime Cold & Flu Softgels — Kroger, 24 softgels, $7.99 (33¢ per softgel)
- Vicks NyQuil Cold & Flu LiquiCaps — Walmart, 48 softgels, $19.47 (41¢ per softgel)
- CVS Health Nighttime Cold & Flu Relief Softgels — CVS, 24 softgels, $10.49 (44¢ per softgel)
- Walgreens NightTime Cold & Flu Softgels — Walgreens, 24 softgels, $10.49 (44¢ per softgel)
- Vicks NyQuil Cold & Flu LiquiCaps — Amazon, 48 softgels, $20.99 (44¢ per softgel)
- Vicks NyQuil Cold & Flu LiquiCaps — Target, 48 softgels, $21.49 (45¢ per softgel)
Where to find it
Look for the “Cough, Cold & Flu” aisle sign.
Good to know
- NyQuil Cold & Flu LiquiCaps contain no decongestant. Vicks NyQuil Severe Cold & Flu LiquiCaps add phenylephrine, so they are a different product.
- Vicks NyQuil Ultra Concentrated Cold & Flu LiquiCaps and NyQuil High Blood Pressure Cold & Flu LiquiCaps contain 10 mg dextromethorphan per LiquiCap — less than the 15 mg in regular NyQuil Cold & Flu LiquiCaps — even though both boxes say "Max Strength".