Acetaminophen 500 mg / Diphenhydramine HCl 25 mg (PM)
Tylenol and its twins. Pain reliever / nighttime sleep aid. Active ingredients: Acetaminophen 500 mg + Diphenhydramine HCl 25 mg.
13 options at Costco, Walmart, Target, Amazon, Kroger, CVS, Walgreens. Cheapest: 3.7¢ per pill; typical Tylenol: 14¢ per pill. Prices are estimates from Oct 2026.
Cheapest options
- Kirkland Signature Extra Strength Acetaminophen PM Caplets — Costco, 350 pills, $12.99 (3.7¢ per pill)
- Equate Extra Strength Pain Reliever PM Caplets — Walmart, 100 pills, $3.97 (4.0¢ per pill)
- up&up Pain Reliever PM Caplets — Target, 100 pills, $4.99 (5.0¢ per pill)
- Amazon Basic Care Acetaminophen PM Extra Strength Caplets — Amazon, 150 pills, $7.99 (5.3¢ per pill)
- Kroger Extra Strength Acetaminophen PM Caplets — Kroger, 100 pills, $5.49 (5.5¢ per pill)
- CVS Health Extra Strength Acetaminophen PM Caplets — CVS, 100 pills, $9.79 (9.8¢ per pill)
- Walgreens Pain Reliever PM Extra Strength Caplets — Walgreens, 100 pills, $9.99 (10.0¢ per pill)
- Tylenol PM Extra Strength Caplets — Amazon, 225 pills, $22.97 (10¢ per pill)
Where to find it
Look for the “Pain Relief” aisle sign.
Good to know
- Tylenol PM is the Extra Strength dose of acetaminophen (500 mg) plus diphenhydramine HCl 25 mg per caplet.
- Unisom PM Pain is a different mix despite the similar name: acetaminophen 325 mg plus diphenhydramine HCl 50 mg.
- Advil PM, Motrin PM and Aleve PM use an NSAID (ibuprofen or naproxen) instead of acetaminophen.