Acetaminophen 500 mg (Extra Strength)
Tylenol and its twins. Pain reliever / fever reducer. Active ingredients: Acetaminophen 500 mg. Also sold as Excedrin Rapid Relief.
18 options at Costco, Walmart, Amazon, Target, Kroger, CVS, Walgreens. Cheapest: 1.5¢ per pill; typical Tylenol: 13¢ per pill. Prices are estimates from Oct 2026.
Cheapest options
- Kirkland Signature Extra Strength Acetaminophen Caplets, 500 mg — Costco, 1000 pills, $14.99 (1.5¢ per pill)
- Equate Extra Strength Acetaminophen Caplets, 500 mg — Walmart, 500 pills, $9.48 (1.9¢ per pill)
- Amazon Basic Care Extra Strength Acetaminophen Caplets, 500 mg — Amazon, 500 pills, $10.49 (2.1¢ per pill)
- Equate Extra Strength Acetaminophen Caplets, 500 mg — Walmart, 100 pills, $2.98 (3.0¢ per pill)
- up&up Extra Strength Acetaminophen Caplets, 500 mg — Target, 100 pills, $3.79 (3.8¢ per pill)
- Kroger Extra Strength Acetaminophen Caplets, 500 mg — Kroger, 100 pills, $4.49 (4.5¢ per pill)
- CVS Health Extra Strength Acetaminophen Caplets, 500 mg — CVS, 100 pills, $8.29 (8.3¢ per pill)
- Walgreens Extra Strength Pain Reliever Caplets, 500 mg — Walgreens, 100 pills, $8.49 (8.5¢ per pill)
Where to find it
Look for the “Pain Relief” aisle sign.
Good to know
- Store-brand "Extra Strength Acetaminophen" and "Extra Strength Pain Reliever" caplets contain the same 500 mg of acetaminophen as Tylenol Extra Strength.
- Tylenol Extra Strength Rapid Release Gels are also 500 mg of acetaminophen — the gelatin coating is what differs, not the dose.
- Excedrin Rapid Relief is acetaminophen 500 mg alone, while Excedrin Extra Strength and Excedrin Migraine add aspirin and caffeine — same brand, different drugs.